Reproductive (Endocrine)
control of reproduction
CIDR®-S/G
Ingredient - progesterone
Use - synchronization of the estrus cycle for fixed-time insemination or controlled breeding; out of season or in-season breeding of sheep and goats
Route of administration - vaginal pessary
Not licensed for use in the U.S. Not commercially available in the U.S.
Dosage - Day 1, insert CIDR in vagina of animal. Day 14, remove pessary
FSH-P Injectable
Ingredient - Follicle stimulating hormone
Availability - veterinary prescription
FDA approved use - used as a supplemental source of follicle stimulating hormone where there is general deficiency.
Route of administration - injectible
Dosage - 5-25 mg. FSH-P should be added to sterile water for injection or sodium chloride injection.
Withdrawal - none
Lutalyse® - Prostaglandin F2
Ingredient - Dinoprost tromethamine
FDA approved use - for luteolysis to control timing of estrus in estrus cycling and clinically anestrous cattle that have a corpus luteum. Not approved for use in sheep and goats in U.S. Refer to extra-label use.
Route of administration - intramuscular (IM) injection
Dosage - 5 ml (equivalent to 25 mg of dinoprost).
Precaution - Do not administer to pregnant animals, as abortion may result.
Withdrawal - none
MGA® - Melengestrol acetate
Ingredient - Melengestrol acetate
Availability - over the counter
FDA approved use - for increased rate of weight gain, improved feed efficiency, and suppression of estrus (heat) in heifers. Not approved for use in sheep and goats in U.S. Refer to extra-label use.
Route of administration - oral feed additive
Dosage - Feed at levels of 0.25 mg to 0.50 mg melengestrol acetate/head/day for 10 days.
Withdrawal - none
P.G. 600®
Ingredients - Serum gonadotropin (PMSG) and chorionic gonadotropin (HCG)
Availability - over the counter
FDA-approved use - induction of estrus in prepuberal gilts and and weaned sows.
Not approved in the U.S. for use in sheep and goats. Refer to extra-label drug use.
Route of administration - subcutaneous (SQ) injection
Dosage - 400 IU serum gonadotropin with 200 IU chorionic
gonadotropin/5 ml dose/animal.
Withdrawal - none
Syncro-Mate (Chronogest®)
Ingredient - Flurogestone acetate
FDA approved use - for synchronizing estrus/ovulation in cycling adult ewes during their normal breeding season.
Availablity - over the counter
Route of administration - intravaginal sponge
Dosage - Using the applicator provided, insert sponge (45 mg) into ewe's vagina 13 days before desired start of breeding.
Precautions: use plastic or rubber gloves when handling large numbers of sponges to minimize exposure to the drug. Do not leave the sponge in the vagina for more than 21 days. Do not use in young ewes that have not had lambs.
Withdrawal - 30 days
Syncro-Mate-B®
Ingredient - Norgestomet
Availability - over the counter
FDA approved use - use for the synchronization of estrus/ovulation in cycling
heifers.
Not approved in the U.S. for sheep and goats.
Route of administration - ear implant
Dosage - insert 1/2 or one 6 mg implant SQ in the ear
Withdrawal - none
Veramix Sponges
Ingredient - medroxyprogesterone acetate
Availability - over the counter (Canada)
Use - syncronization of estrus (ovululation)
Route of administration - vaginal sponge
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